Mean patient weight was 71 kg (range 50–85 kg). 73-year-old woman with a peripheral pulmonary embolism (white arrows). is may be subject to change since administration o, Institute of Clinical Radiology and Nuclear Medicine, University Medical. Conclusions: Subsequently, virtual monoenergetic images (MEI+) were reconstructed at five different keV levels (40, 55, 70, 85, 100) and compared to the standard linearly blended (M_0.8) CTpv images. The Volume of IV contrast needed decreased by 40 % in group B compared to group A. Objectives Concluding this chapter, we discuss the potential pitfalls associated with DECT. The study involved a retrospective analysis of 129 patients, 69 males (average age 58 years), 60 females (average age 56 years) who underwent a DE-CTPA at a tertiary referral hospital. A total of 20 pa, right ventricular dysfunction on echocardiography, mass-index between all three groups (all p, frequency-split technique is used which decomposes both the low keV images (in which iodine pix, high contrast to the surrounding tissue, typ, lower spatial frequency stack at low keV is co. a noise perspective to combine the benets of both images stacks. CT pulmonary angiography. One hundred patients with suspected pulmonary embolism (PE) were randomly divided into two groups (n = 50 each; group A, 100 kVp, 1.2 pitch, 60 ml of contrast medium and filtered back projection algorithm; group B, 80 kVp, 2.2 pitch, 20 ml of contrast medium and sinogram affirmed iterative reconstruction). CT pulmonary angiography is the currently accepted standard in ruling out acute pulmonary embolism. Its main use is to diagnose pulmonary embolism (PE). PDF. Fifteen rats were constructed into chronic kidney disease models (the model group). 3 The peak of serum creatinine level and the ratio of the increase in the creatinine level of 44.2 μ mol/L or more and the increase of 88.4 μ mol/L or more during three days after angiography and a change in the creatinine level during seven days after angiography were determined. METHODS:Twenty-two male Sprague-Dawley (SD) rats were included as experimental subjects. To illustrate the normal imaging appearance of lungs on perfusion imaging. Two independent readers analyzed all CTA in a randomized order for the localization of emboli, diagnostic confidence, and image quality. This study aimed to determine the overall positivity rate of CTPA examinations and understand the factors that affect the yield of the CTPA examination. Purpose: Furthermore, virtual non-contrast (VNC) imaging can reduce the radiation exposure to the patient by omitting the need for a conventional non-contrast CT scan. By combining several procedures in a CTPA protocol, the contrast media dose can be minimized. Materials and Methods: The study was performed according to the regulations of the institutional review board. In this chapter we review clinically established applications of DECT for the main body regions from head to toe. Results: 2–4 CTPA is a standard procedure that obtains a CT volume while intravenously injected iodinated contrast media (CM) opacifies the pulmonary arteries. To perform CT pulmonary angiography (CTPA) using a minimal amount of iodinated contrast media. Springer Nature journal content, brought to you courtesy of Springer Nature Customer Service Center GmbH (“Springer Nature”). The patients were randomly divided into two groups, and were respectively treated with iodixanol and iopromide for coronary arteriography. Academia.edu no longer supports Internet Explorer. The optimal opacification of a CTPA examination is 250 Hounsfield Units (HU) [5][6][7]. VMI+40 (1161.500 HU) yielded a statistically significant increase in median attenuation within the pulmonary trunk compared to the LB120 (304.400 HU), with a median difference between monoenergetic reconstruction and standard dual energy of data sets of 827.5 HU (P < .001). To determine the risk of emergent dialysis and short-term mortality following intravenous iodinated contrast material exposure. The objective of our study was to exposit the shifting perspectives on contrast-induced nephropathy (CIN) for IV low-osmolar iodinated contrast media. ... With the virtual monoenergetic reconstructions, the attenuation of iodine is augmented and the CM dose can be substantially reduced. Main pulmonary arteries at 50 keV and peripheral pulmonary arteries at 40 keV datasets provided the highest contrast-to-noise-ratio (CNR) for both the standard DE CTPA and the optimized protocol, with significantly higher CNR values for the standard DE CTPA protocol (p < 0.05). pulmonary arteries of a low contrast media dual-energy CTP, spectral (VPS) image, and virtual monoenergetic spectral (VMS) images at a level of 40, polyenergetic spectral datasets (VPS) and virtual monochromatic spectral (VMS) datasets of a low co, observed between the three protocols (standard CTP, with decreasing energy levels for the 40–100, For the peripheral pulmonary arteries, the 50, arteries of a low contrast media dual-energy CTP, image, and virtual monoenergetic spectral (VMS) images at a level of 40, pulmonary arteries. The introduction of dual-energy CT has resulted in the ability to add functional and prognostic information beyond the morphologic assessment of the pulmonary arteries and potentially offer improved image quality without additional radiation burden. In patients with acute or chronic renal insufficiency, Meyer et al. Computed MEI+ at low keV levels allow for improved vessel contrast and visualisation of incidental pulmonary embolism in patients with portal-venous phase CT scans by substantially increasing CNR and SNR. RESULTS:Ten weeks after model construction, the bodyweight of rats in the model group was significantly lower than that in the sham-operated group. Improvements in the technical success rate and reliability of this modality will mean more widespread use in the future. Ongoing research in the use of V/Q PET/CT demonstrates superior temporal and spatial resolution and quantitative capabilities compared to SPECT-CT; this modality will likely play an increasing role in the detection and characterization of pulmonary embolism. For the localizations with emboli, both the sensitivity (83.7% at 80 kVp and 83.6% at 120 kVp; P = 0.921) and the specificity (97.2%, at 80 kVp and 97.8% at 120 kVp; P = 0.463) were not significantly different at the 2 tube voltages. 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Rationale and objectives: The aim of this study was to investigate whether dual-energy (DE) pulmonary CT angiography (CTPA) in combination with a noise optimized virtual monoenergetic imaging algorithm allows for a reduction of CM. thought, but there are lingering questions. Impact of sinogram armed iterative reconstruction (SAFIE) algorithm on image q, . Results: Objective CT pulmonary angiography (CTPA) is one of the most commonly ordered CT imaging tests. standard investigation—pulmonary angiography—is invasive and carries a recognised morbidity and mortality.9 Furthermore, a normal angiogram is associated with a 1.6% incidence of venous thromboembolism in the following year.10 Computed tomographic pulmonary angiography (CT pul-monary angiography) is increasingly used in the diagnosis of However, computed tomography pulmonary angiography was the dominant modality of diagnosis, even in pregnancy and severe renal insufficiency. Conclusion: Substantially improved iodine attenuation at lower kiloelectron volt levels and reduced beam-hardening artifacts at higher kiloelectron volt levels have been demonstrated from all major manufacturers of dual-energy CT units. program announces that the, Aim: Diabetes mellitus and renal dysfunction can cause the nephrotoxic effects induced by low-osmolar contrast media. A 73 year old state governor, a heavy drinker for 40 years, developed advanced nutritional cirrhosis of the liver, pancreatic Conclusion: The effective dose for group A was lower by 80% compared to group B (P < 0.001). 2. Regarding vessel segments, mean enhancement scored ≥ 255.5 except weight-class 5. The increased attenuation of iodine in low-kVp CT protocols is used to reduce the amount of CM administered in CTPA. Computed tomographic pulmonary angiography (CTPA) using helical (or spiral) CT has emerged as the preferred diagnostic test for PE. patients with suspected pulmonary embolism. Subjective image quality showed no difference between the two groups (P = 0.559) with good interobserver agreement (κ = 0.647). The CT tube voltage was either 80 kVp (group A, with PE and group B, with no PE) or 120 kVp (group C, with PE and group D, with no PE). To assess image quality, radiation dose, and diagnostic accuracy of 70-kVp high-pitch computed tomography pulmonary angiography (CTPA) using 40 mL contrast agent and sinogram affirmed iterative reconstruction (SAFIRE) compared to 100-kVp CTPA using 60 mL contrast agent and filtered back projection. 50 patients with acute/chronic renal failure were examined on a 3rd generation dual-source CT with an optimized DE CTPA protocol and a low CM injection protocol (5.4 g iodine). Methods As media representatives gather in Mannheim – Heidelberg University, Mannheim. is is an unnecessary contrast media ap, patients with renal risk factors to additio, entirely explicit whether the iodine amoun, 5-year survival rate of patients with arterioven, detector CT systems become clinically available, both a reduced radia, may become feasible by k-edge subtraction imagin, radiation dose. Three groups with 40 consecutive patients each underwent either standard single-source 100 kVp (120 mAs; group A), single-source 70 kVp (208 mAs; group B), or dual-source 70 kVp CTPA (416 mAs; group C). The Ascending aorta average density decreased from 250 HU in group A to 130 HU in group B with P value <.001. 1023-1029 Article Download PDF View Record in Scopus Google Scholar Objectives: The aim is to evaluate contrast enhancement and density distribution in non-ECG-synchronized high-pitch aortoiliacal CT-angiography. Objectives To perform CT pulmonary angiography (CTPA) using a minimal amount of iodinated contrast media. Further imaging may be necessary, consisting of either repeat CT pulmonary angiography with an increased delay or pulmonary angiography. Among 38 025 patients with confirmed PE (53.1% female, age: 67.3±17 years), computed tomography pulmonary angiography was the dominant modality of diagnosis in all RIETE enrollees (78.2% [99% CI, 77.6-78.7]); including pregnant patients (58.9% [99% CI, 47.7%-69.4%]) and patients with severe renal insufficiency (62.5% [99% CI, 59.9-65.0]). CT PULMONARY ANGIOGRAMMr. These Terms are supplementary and will apply in addition to any applicable website terms and conditions, a relevant site licence or a personal, subscription. e diagnosis of PE and i, PE (blinded to the previous rating). Objectives 62-year-old woman with suspected pulmonary embolism. [9][10][11][12][13][14][15][16]. For Creative Commons-licensed articles, the terms of the Creative Commons license used will, We collect and use personal data to provide access to the Springer Nature journal content. Dual-energy computed tomography (DECT) has evolved from a research tool to an established clinical imaging modality since its first commercial introduction in the mid-2000s. For reduction of beam-hardening artifacts, VM imaging at 120 keV is useful for the initial assessment. Methods: 84 patients underwent clinically indicated thoracoabdominal CTA between February 2011 and May 2012 using high-pitch technique for arterial phase and an individually tailored contrast-media protocol depending on weight-class and scan duration. Likewise, there was no signicant dierence in the median imag, negative ndings were observed, resulting in a sensiti, dierences to the baseline evaluation for the standar, serum creatinine levels of those patients with acute kidney failure d, sample size, it has to be noted that the s, ard CM dose. Join ResearchGate to find the people and research you need to help your work. Pulmonary angiography, the diagnostic ORIGINAL ARTICLE A retrospective comparison of smart prep and test bolus multi-detector CT pulmonary angiography protocols Tara Suckling1, Tony Smith2 & Warren Reed3 1Medical Imaging Department, Tamworth Rural Referral Hospital, Tamworth, New South Wales, Australia 2University Department of Rural Health, The University of Newcastle, Tamworth, New South Wales, Australia Identically for all readers, pulmonary embolism (PE) was detected in 1/47 participants. Non-thrombotic PE does not represent a distinct clinical syndrome. Over the past two decades, however, catheter angiography has become almost entirely supplanted by CT angiography (CTA), which is now the … Within this cohort, the risks of AKI acute kidney injury ( OR odds ratio , 0.94; 95% confidence interval [ CI confidence interval ]: 0.83, 1.07; P = .38), emergent dialysis ( OR odds ratio , 0.96; 95% CI confidence interval : 0.54, 1.60; P = .89), and 30-day mortality (hazard ratio [ HR hazard ratio ], 0.97; 95% CI confidence interval : 0.87, 1.06; P = .45) were not significantly different between the contrast group and the noncontrast group. Both sensitivity analyses revealed similar results. This study aims to prove that the test bolus technique provides a better selective imaging study of the pulmonary arterial system in comparison to the automatic bolus-tracking technique. CT pulmonary angiography (CTPA) is a medical diagnostic test that employs computed tomography to obtain an image of the pulmonary arteries. This retrospective study examined the feasibility of utilising a noise-optimised monoenergetic reconstruction of the dual-energy computed tomography pulmonary angiogram (DE-CTPA) as an additional protocol to increase vessel opacification. This IRB-approved study comprised 150 patients with suspected pulmonary embolism (78 male; mean age 65 ± 17years). A prospective study included 600 patients, classified into 2 groups where each group consisted of 300 patients. 4841 slices with mean density 280.0 ± 63 HU are analyzed. What the Radiologist Needs to Know1, Computed tomography pulmonary embolism index for the assessment of survival in patients with pulmonary embolism, Pulmonary Embolism Outcome: A Prospective Evaluation of CT Pulmonary Angiographic Clot Burden Score and ECG Score, The association between the proximal extension of the clot and the severity of pulmonary embolism (PE): a proposal for a new radiological score for PE, Underdiagnosis of Pulmonary Embolism: A recurrent nightmare of Surgeons. The average score was increased by 35 % (from 1.75 in group A to 2.8 in group B with P value < .001). Kocher, et al.CT pulmonary angiography: using decision rules in the emergency department J Am Coll Radiol, 12 (2015), pp. Image noise significantly increased at 40 keV MEI+ compared to all other MEI+ reconstructions and CTpv (p < 0.001). with respect to the Springer nature journal content and all parties disclaim and waive any implied warranties or warranties imposed by law. The two main approaches in recent studies minimizing the CM dose in CTPA are the dual-energy monoenergetic reconstruction technique and the high-pitch, low-kVp technique. tomographic (CT) pulmonary angiography has been evaluated with meta-analysis and has dem-onstrated sensitivities of 53%–100% and speci-ficities of 83%–100% (6), wide ranges that are explained in part by technologic improvements over time. Premium PDF Package. Materials and methods: CNR did not differ between the groups (P = 0.202). Results: All patients with PE were correctly identified with both protocols, corresponding to a sensitivity of 100% at the patient level. arterial enhancement at dierent iodine ow ra, is research project is part of the Researc, Ministry of Education and Research (BMBF) within the Fra, License, which permits use, sharing, adaptation, distribution and reproduction in any medium or, format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-, ative Commons license, and indicate if changes were made. (email: Content courtesy of Springer Nature, terms of use apply. In 2005 another 4-slice CT scanner (HiSpeed, GE Healthcare, UK) was installed and the existing CT scanners were upgraded to 16-slice CT machines (LightSpeed, GE Healthcare, UK). Images were acquired with a 3rd generation DE-CT system in DE mode (100/Sn150 kV) and activated tube current modulation 90 s after contrast agent administration. including merchantability or fitness for any particular purpose. Fir, a decision-making with sucient diagnostic condence for co, scans were performed on dierent CT scanner, and can be used to save contrast media when using VMS reco, tion in diagnostic accuracy, vessel opacica, ideal when reducing the total iodine amount down to 5.4, patients undergoing single-pass dual-energy comp. The imaging modalities included computed tomography pulmonary angiography, ventilation/perfusion scanning, pulmonary angiography, a combination of these tests, or PE signs and symptoms plus imaging-confirmed proximal deep vein thrombosis but no chest imaging. Nonetheless, each DECT exa, Several study limitations have to be noted. e standar, for re-administration of iodine CM during the f, increase in serum creatinine from baseline by, (ROI) placement in the pulmonary trunk. A total of 6902 patients (4496 CKD stage III, matched: 1220 contrast and 1220 noncontrast; 2086 CKD stage IV-V, matched: 491 contrast and 491 noncontrast) were included in the study. It may be due to a variety of embolic materials and result in a wide spectrum of clinical presentations, making the diagnosis difficult. CT pulmonary angiogram CT pulmonary angiogram (CTPA) is a medical diagnostic test that employs computed tomography (CT) angiography to obtain an image of the pulmonary arteries. Subjective image quality ratings regarding enhancement and noise were highest for group C (1.73±0.62 and 2.03±0.66, respectively). Recent findings: To evaluate noise-optimized monoenergetic postprocessing of dual-energy CT (DE-CT) on image quality in patients with incidental pulmonary embolism in single-pass portal-venous phase CT (CTpv). Conclusion: The purpose of the study was to evaluate 70 kVp dual-source computed tomography pulmonary angiography (CTPA) with reduced iodine load in comparison with single-source 70 and 100 kVp CTPA with standard iodine load regarding image quality and radiation dose. The 1:1 matching on the basis of the propensity score yielded a cohort of 21 346 patients (10 673 in the contrast group, 10 673 in the noncontrast group). In this institutional review board-approved retrospective study, all patients with CKD who received a contrast-enhanced (contrast group) or unenhanced (noncontrast group) computed tomographic scan from January 1, 2000, to August 1, 2013 were identified. With the exception of severe air and fat embolism, the haemodynamic consequences of non-thrombotic emboli are usually mild. Sensitivity analyses examining only patients with stable prescan serum creatinine levels and incorporating intravenous fluid administration at the time of the CT scan into the model were also performed. Historically, catheter-directed pulmonary angiography has been used most commonly for the diagnosis of suspected pulmonary embolism (PE). PDF. When performed in experienced clinical centers with use of validated scanning protocols, helical CTPA is a useful tool to rule out PE in patients with compatible clinical symptoms with a sensitivity of 83% and specificity of 96%. Linear blended 120 kilovoltage (kV) images (LB120) dual-energy (DE) data sets (50% 100 kV and 50% 140 kV) were compared to noise-optimised virtual monoenergetic image reconstruction (VMI+) at 40 kiloelectron volts (VMI+40). The reference standard for the presence of emboli involved consensus reading and assessment of available clinical data and findings with additional imaging modalities. Axial slices of main pulmonary arteries of a low contrast media dual-energy CTPA: (A) mixed 0.8-weighted virtual polyenergetic spectral (VPS) image, and virtual monoenergetic spectral (VMS) images at a level of 40 keV (B), 50 keV (C), 60 keV (D), 70 keV (E), 80 keV (F), 90 keV (G) and 100 keV (H). No pulmonary embolism was missed on the optimized CM protocol. Alternatively, repeat CT pulmonary angiography or conventional pulmonary angiography may be performed to evaluate for pulmonary embolism. 12) are the most popular and investigated applications of DECT that can be used to improve detection and conspicuity of disease as well as objective and subjective image quality. The mean attenuation ± standard deviation in the pulmonary trunk was 325 ± 72 Hounsfield unit (range 165–531 Hounsfield unit). Incomplete reporting has been identified as a major source of avoidable waste in biomedical research. Chest diameter, dose-length product, intravascular signal attenuation, image noise, signal to noise ratio (SNR), and contrast to noise ratio (CNR) were compared. The number of end-stage renal disease patients in the world was increasing year by year. CT pulmonary angiography In 2000, CTPAs were performed on single or 4 – slice scanners (HiSpeed, GE Healthcare, UK). Computed tomography pulmonary angiography (CTPA) is used for diagnosis. Eighty patients underwent CTPA at either 70 kVp (group A, n = 40; 3.2 pitch, 40 mL contrast medium, and SAFIRE) or 100 kVp (group B, n = 40; 1.2 pitch, 60 mL contrast medium, and filtered back projection). Compared with standard 100 kVp CTPA, single-source 70 kVp CTPA allows for significant radiation dose savings with comparable SNR and CNR, whereas dual-source 70 kVp CTPA results in a superior objective image quality albeit a reduction of iodine concentration. Volume and flow rate of injected contrast medium was lower with the 80 kVp protocol (75 mL at 3 mL/s) compared with the 120 kVp protocol (100 mL at 4 mL/s). Introduction: Methods 47 patients (25 females) with mean … The safety, costs, and downstream effects of these tests on PE-related and non-PE-related outcomes warrant further investigation. Closing in on the  Edge: Coronary CT Angiography at 100, 80, and 70 V-Ini, . This phantom study investigated the effects of patient shielding and scan length reduction on the fetal and maternal ionising radiation dose from CTPA. Criteria to be used for Chest CTA or a CT is requested for Pulmonary Emboli which cannot be approved based on Interqual or Milliman criteria. Moving beyond planar ventilation/perfusion (V/Q) scintigraphy, nuclear imaging offers several new approaches, including the use of single photon emission computed tomography (SPECT) and SPECT/CT resulting in superior diagnostic performance and a decrease in nondiagnostic studies, potentially surpassing the diagnostic capabilities of computed tomography pulmonary angiography. The possibility to characterize the composition of different human tissues and the quantification of certain materials like iodine, calcium, or fat have shown clinical benefit for various body regions. This resulted in a 64% decrease in radiation and 23% decrease in iodine dose administered. Two observers rated subjective image quality regarding intravascular enhancement and image noise using 5-point scales. Results: Optimal opacification of the pulmonary vasculature is a fundamental factor of a diagnostic quality computed tomography pulmonary angiogram (CTPA). Patients in the contrast and noncontrast groups were compared following propensity score-based 1:1 matching to reduce intergroup selection bias. purposes, Springer Nature considers academic use (by researchers and students) to be non-commercial. The Challenges in Assessing Contrast-Induced Nephropathy: Where Are We Now? To illustrate the role of pulmonary perfusion in the diagnosis of acute and chronic pulmonary thromboembolism. Patients and methods: Treatment is mostly supportive but may differ according to the type of embolic material and clinical severity. There are two principal approaches for performing a CTPA of high diagnostic quality: Virtual monoenergetic imaging (VMI) and multi-material decomposition (MMD) imaging (see Chap. Method: CTPA was introduced in the 1990s as an alternative to ventilation/perfusion scanning, which relies on radionuclide imaging of the blood vessels of the lung. In 2000, CTPAs were performed on single or 4 – slice scanners (HiSpeed, GE Healthcare, UK). To improve the quality of reporting of diagnostic accuracy studies, the Standards for Reporting of Diagnostic Accuracy Studies (STARD) statement was developed. This article analyzes the effects of iodixanol and iopromide on radiographic contrast nephropathy in high-risk patients and assesses the clinic safety of using iodixanol in high-risk patients. Abstract Guidelines for the evaluation of venous thromboembolism (VTE) include a history and physical examination in conjunction with computed tomographic pulmonary angiography (CTPA), Doppler ultrasonography, and D‐dimer measurements. Radiation doses were compared. CT Scan angiography of the thoracic aorta (SIEMEN) - CLVT Động mạch chủ ngực - Duration: 12:19. A volume of 70 mL of contrast material with 400 mg I/mL (groups A, B) or 300 mg I/mL (group C) was administered. 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And all parties disclaim and waive any implied warranties or warranties imposed law... ± 72 Hounsfield unit ( range 50–85 kg ) consolidation or atelectasis two independent readers analyzed all CTA a. 50–85 kg ) B ) test its prognostic significance Hounsfield unit ( range kg... Was missed on the optimized CM protocol all groups from consolidation or atelectasis future. Patient of the iopromide group... against which all other modalities have beenmeasured research that... Hounsfield Units ( HU ) [ 5 ] [ 10 ] [ 13 ] [ 11 ] [ 14 [... Results: in mean 53.1 ± 7.4 ml contrast-medium is administered for aortoiliacal examination be to!

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